Isocitrate dehydrogenase (IDH) inhibitor, BAY-1436032, Purity ≥98%

Synonym: 1803274-65-8; BAY1436032; BAY 1436032; 3-(2-{[4-(Trifluoromethoxy)phenyl]amino}-1-[(1R,5R)-3,3,5-trimethylcyclohexyl]-1,3-benzodiazol-5-yl)propanoic acid; 3-[2-[4-(Trifluoromethoxy)anilino]-1-[(1R,5R)-3,3,5-trimethylcyclohexyl]benzimidazol-5-yl]propanoic acid; Isocitrate dehydrogenase (IDH) inhibitor

CAS Number: 1803274-65-8
Compound CID: 118310260

Product Size

5 mg; 10 mg; 50 mg; 100 mg

Price

Datasheet

Datasheet

MSDS

MSDS

Properties

Description

BAY-1436032, soluble in DMSO and ethanol and insoluble in water, is an effective metabolism inhibitor, that has the ability to prevent the pathway of cell metabolism by inhibiting isocitrate dehydrogenase (IDH). The molecular weight of the compound is 489.54, and its molecular formula is C₂₆H₃₀F₃N₃O₃.

Molecular Weight

489.54

Molecular Formula

C₂₆H₃₀F₃N₃O₃

Form

Lyophilized powder

Purity

≥98%

Impurities

Free from inappropriate visible particulates, foreign matter, discoloration, or other defects.

Solubility

In vitro: DMSO: 85 mg/mL (173.63 mM); Water: insoluble; Ethanol: 85 mg/mL (173.63 mM)

Identity

Confirmed by NMR/HPLC/MS.

Applications

BAY-1436032 can be studied extensively for its potential therapeutic applications in the treatment of cancers with IDH1 mutations, such as gliomas and AML.