JAK inhibitor Abrocitinib, Purity ≥98%

Synonym: Abrocitinib; 1622902-68-4; PF-04965842; Cibinqo; N-[cis-3-[Methyl(7H-pyrrolo[2,3-d]pyrimidin-4-yl)amino]cyclobutyl]propane-1-sulfonamide; JAK inhibitor

MDL: MFCD30187577
CAS Number: 1622902-68-4
Compound CID: 78323835

Product Size

5 mg; 10 mg; 25 mg; 50 mg; 100 mg

Price

Datasheet

Datasheet

MSDS

MSDS

Properties

Description

Abrocitinib, soluble in DMSO and insoluble in ethanol and water, is an available JAK small molecule inhibitor with potential antineoplastic activity. It targets JAK1, JAK2, and Tyk2.

Molecular Weight

323.415

Molecular Formula

C₁₄H₂₁N₅O₂S

Targets

JAK1: 29 nM; JAK2: 803 nM; Tyk2: 1253 nM

Form

Lyophilized powder

Purity

≥98%

Solubility

DMSO: 58 mg/mL (179.34 mM); Water: Insoluble; Ethanol: Insoluble

Identity

Confirmed by NMR/HPLC/MS.

Stability

The product is stable for three years when stored at the recommended temperature in lyophilized powder.

Applications

Abrocitinib is used to explore JAK1 inhibition for the treatment of autoimmune and inflammatory diseases.

Storage

Store at -20ºC.