JAK inhibitor AZ-960, Purity ≥98%

Synonym: 905586-69-8; AZ-960; AZ 960; AZ960; (S)-5-Fluoro-2-((1-(4-fluorophenyl)ethyl)amino)-6-((5-methyl-1H-pyrazol-3-yl)amino)nicotinonitrile; (S)-5-Fluoro-2-(1-(4-fluorophenyl)ethylamino)-6-(5-methyl-1H-pyrazol-3-ylamino)nicotinonitrile; JAK inhibitor

CAS Number: 905586-69-8
Compound CID: 25099184

Product Size

5 mg; 10 mg; 25 mg; 50 mg; 100 mg

Price

Datasheet

Datasheet

MSDS

MSDS

Properties

Description

AZ-960, soluble in DMSO and ethanol and insoluble in water, is an available JAK small molecule inhibitor with potential antineoplastic activity. It targets JAK2 and JAK2.

Molecular Weight

354.4

Molecular Formula

C₁₈H₁₆F₂N₆

Targets

JAK2: <3 nM; JAK2: 0.45 nM (Ki)

Form

Lyophilized powder

Purity

≥98%

Solubility

DMSO: 70 mg/mL (197.54 mM); Water: Insoluble; Ethanol: 3 mg/mL (8.46 mM)

Identity

Confirmed by NMR/HPLC/MS.

Stability

The product is stable for three years when stored at the recommended temperature in lyophilized powder.

Applications

AZ-960 can be utilized for investigating JAK2 inhibition and its consequent effects on cancer cell proliferation and immune response.

Storage

Store at -20ºC.