JAK inhibitor AZD1480, Purity ≥98%

Synonym: AZD1480; 935666-88-9; AZD-1480; (S)-5-Chloro-N2-(1-(5-fluoropyrimidin-2-yl)ethyl)-N4-(5-methyl-1H-pyrazol-3-yl)pyrimidine-2,4-diamine; JAK inhibitor

CAS Number: 935666-88-9
Compound CID: 16659841

Product Size

5 mg; 10 mg; 50 mg; 200 mg

Price

Datasheet

Datasheet

MSDS

MSDS

Properties

Description

AZD1480, soluble in warmed DMSO and insoluble in water and ethanol, is an available JAK small molecule inhibitor with potential antineoplastic activity. It targets JAK2.

Molecular Weight

348.8

Molecular Formula

C₁₄H₁₄ClFN₈

Targets

JAK2: 0.26 nM

Form

Lyophilized powder

Purity

≥98%

Solubility

Warmed DMSO: 68 mg/mL (194.96 mM); Water: Insoluble; Ethanol: Insoluble

Identity

Confirmed by NMR/HPLC/MS.

Applications

AZD1480 is used to study the inhibition of JAK2/STAT3 signaling in cancer, inflammation, and myeloproliferative disorders.