JAK inhibitor Baricitinib, Purity ≥98%

Synonym: Baricitinib; 1187594-09-7; Olumiant; INCB028050; LY3009104; INCB 028050; 2-(3-(4-(7H-Pyrrolo[2,3-d]pyrimidin-4-yl)-1H-pyrazol-1-yl)-1-(ethylsulfonyl)azetidin-3-yl)acetonitrile; JAK inhibitor

MDL: MFCD21608464
CAS Number: 1187594-09-7
Compound CID: 44205240

Product Size

5 mg; 10 mg; 25 mg; 50 mg; 100 mg

Price

Datasheet

Datasheet

MSDS

MSDS

Properties

Description

Baricitinib, soluble in DMSO and insoluble in ethanol and water, is an available JAK small molecule inhibitor with potential antineoplastic activity. It targets JAK1, TYK2, c-Met, Chk2, JAK2, and JAK3.

Molecular Weight

371.4

Molecular Formula

C₁₆H₁₇N₇O₂S

Targets

JAK1: 5.9 nM; TYK2: 53 nM; c-Met: >10 μM; Chk2: >1 μM; JAK2: 5.7 nM; JAK3: >400 nM

Form

Lyophilized powder

Purity

≥98%

Solubility

DMSO: 65 mg/mL (175 mM); Water: Insoluble; Ethanol: Insoluble

Identity

Confirmed by NMR/HPLC/MS.

Applications

Baricitinib is used in research to evaluate its effectiveness as a JAK1 and JAK2 inhibitor for treating rheumatoid arthritis and other inflammatory diseases.