JAK inhibitor BMS-911543, Purity ≥98%

Synonym: BMS-911543; 1271022-90-2; BMS911543; BMS 911543; N,N-Dicyclopropyl-4-((1,5-dimethyl-1H-pyrazol-3-yl)amino)-6-ethyl-1-methyl-1,6-dihydroimidazo[4,5-d]pyrrolo[2,3-b]pyridine-7-carboxamide; JAK inhibitor

MDL: MFCD22200575
CAS Number: 1271022-90-2
Compound CID: 50922691

Product Size

5 mg; 10 mg; 25 mg; 50 mg; 100 mg

Price

Datasheet

Datasheet

MSDS

MSDS

Properties

Description

BMS-911543, soluble in DMSO and ethanol and insoluble in water, is an available JAK small molecule inhibitor with potential antineoplastic activity. It targets JAK1, JAK2, JAK3, SET-2, and Tyk2.

Molecular Weight

432.52

Molecular Formula

C₂₃H₂₈N₈O

Targets

JAK1: 360 nM; JAK2: 1.1 nM; JAK3: 75 nM; SET-2: 60 nM; Tyk2: 66 nM

Form

Lyophilized powder

Purity

≥98%

Solubility

DMSO: 36 mg/mL (83.23 mM); Water: Insoluble; Ethanol: 22 mg/mL (50.86 mM)

Identity

Confirmed by NMR/HPLC/MS.

Stability

The product is stable for three years when stored at the recommended temperature in lyophilized powder.

Applications

BMS-911543 is used to explore its ability to inhibit JAK2 and its potential therapeutic applications in myeloproliferative neoplasms.

Storage

Store at -20ºC.