Properties
Description
BMS-911543, soluble in DMSO and ethanol and insoluble in water, is an available JAK small molecule inhibitor with potential antineoplastic activity. It targets JAK1, JAK2, JAK3, SET-2, and Tyk2.
Molecular Formula
C23H28N8O
Targets
JAK1: 360 nM; JAK2: 1.1 nM; JAK3: 75 nM; SET-2: 60 nM; Tyk2: 66 nM
Solubility
DMSO: 36 mg/mL (83.23 mM); Water: Insoluble; Ethanol: 22 mg/mL (50.86 mM)
Identity
Confirmed by NMR/HPLC/MS.
Applications
BMS-911543 is used to explore its ability to inhibit JAK2 and its potential therapeutic applications in myeloproliferative neoplasms.