JAK inhibitor Cerdulatinib, Purity ≥98%

Synonym: 1369761-01-2; Cerdulatinib hydrochloride; Cerdulatinib HCl; Cerdulatinib HCl salt; RVT-502 hydrochloride; Cerdulatinib (hydrochloride); JAK inhibitor

CAS Number: 1369761-01-2
Compound CID: 56960607

Product Size

10 mg; 25 mg; 50 mg; 100 mg

Price

Datasheet

Datasheet

MSDS

MSDS

Properties

Description

Cerdulatinib, soluble in warmed DMSO and insoluble in water and ethanol, is an available JAK small molecule inhibitor with potential antineoplastic activity. It targets ARK5, MST1, AMPK, Chk1, FLT3, FLT4, Fms, GCK, ITK, JAK1, and JAK2.

Molecular Weight

482

Molecular Formula

C₂₀H₂₈ClN₇O₃S

Targets

ARK5: 4 nM; MST1: 4 nM; AMPK: 6 nM; Chk1: 42 nM; FLT3: 90 nM; FLT4: 51 nM; Fms: 5 nM; GCK: 18 nM; ITK: 194 nM; JAK1: 12 nM; JAK2: 6 nM

Form

Lyophilized powder

Purity

≥98%

Solubility

Warmed DMSO: 42 mg/mL (87.14 mM); Water: Insoluble; Ethanol: Insoluble

Identity

Confirmed by NMR/HPLC/MS.

Applications

Cerdulatinib is used to investigate the dual inhibition of JAK and SYK kinases in the treatment of hematologic malignancies.