JAK inhibitor Decernotinib, Purity ≥98%

Synonym: Decernotinib; 944842-54-0; Adelatinib; VX-509; Decernotinib(VX-509); VRT-831509; Decernotinib (VX-509); JAK inhibitor

CAS Number: 944842-54-0
Compound CID: 59422203

Product Size

2 mg; 5 mg; 10 mg; 25 mg

Price

Datasheet

Datasheet

MSDS

MSDS

Properties

Description

Decernotinib, soluble in DMSO and warmed ethanol and insoluble in water, is an available JAK small molecule inhibitor with potential antineoplastic activity. It targets JAK1, JAK1, JAK2, JAK3, and TYK2.

Molecular Weight

392.38

Molecular Formula

C₁₈H₁₉F₃N₆O

Targets

JAK1: 11 nM; JAK1: 11 nM (Ki); JAK2: 13 nM (Ki); JAK3: 2.5 nM (Ki); TYK2: 13 nM (Ki)

Form

Lyophilized powder

Purity

≥98%

Solubility

DMSO: 70 mg/mL (178.39 mM); Water: Insoluble; Warmed ethanol: 18 mg/mL (45.87 mM)

Identity

Confirmed by NMR/HPLC/MS.

Stability

The product is stable for three years when stored at the recommended temperature in lyophilized powder.

Applications

Decernotinib is used to explore its selectivity for inhibiting JAK3 and its potential benefits in treating rheumatoid arthritis.

Storage

Store at -20ºC.