JAK inhibitor Filgotinib, Purity ≥98%

Synonym: 1206101-20-3; Filgotinib; GLPG0634; 1206161-97-8; N-(5-(4-((1,1-Dioxidothiomorpholino)methyl)phenyl)-[1,2,4]triazolo[1,5-a]pyridin-2-yl)cyclopropanecarboxamide; JAK inhibitor

MDL: MFCD20527867
CAS Number: 1206161-97-8
Compound CID: 49831257

Product Size

10 mg; 25 mg; 50 mg; 100 mg

Price

Datasheet

Datasheet

MSDS

MSDS

Properties

Description

Filgotinib, soluble in DMSO and insoluble in ethanol and water, is an available JAK small molecule inhibitor with potential antineoplastic activity. It targets JAK1, JAK2, JAK3, and TYK2.

Molecular Weight

425.5

Molecular Formula

C₂₁H₂₃N₅O₃S

Targets

JAK1: 10 nM; JAK2: 28 nM; JAK3: 810 nM; TYK2: 116 nM

Form

Lyophilized powder

Purity

≥98%

Solubility

DMSO: 75 mg/mL (176.26 mM); Water: Insoluble; Ethanol: Insoluble

Identity

Confirmed by NMR/HPLC/MS.

Applications

Filgotinib is used to investigate the inhibition of JAK1 in the treatment of inflammatory bowel diseases and rheumatoid arthritis.