JAK inhibitor Gandotinib, Purity ≥98%

Synonym: GANDOTINIB; 1229236-86-5; LY2784544; LY 2784544; LY-2784544; Gandotinib (LY2784544); 3-(4-Chloro-2-fluorobenzyl)-2-methyl-N-(5-methyl-1H-pyrazol-3-yl)-8-(morpholinomethyl)imidazo[1,2-b]pyridazin-6-amine; JAK inhibitor

MDL: MFCD20482143
CAS Number: 1229236-86-5
Compound CID: 46213929

Product Size

5 mg; 10 mg; 25 mg; 50 mg; 100 mg

Price

Datasheet

Datasheet

MSDS

MSDS

Properties

Description

Gandotinib, soluble in DMSO and ethanol and insoluble in water, is an available JAK small molecule inhibitor with potential antineoplastic activity. It targets JAK2, JAK2, ALK, Aurora A, FGFR2, FGFR3, FLT3, FLT4, JAK1, JAK2 (V617F), and JAK3.

Molecular Weight

469.9

Molecular Formula

C₂₃H₂₅ClFN₇O

Targets

JAK2: 0.288 nM (Ki); JAK2: 2.52 nM; ALK: 138 nM; Aurora A: 168 nM; FGFR2: 32 nM; FGFR3: 106 nM; FLT3: 4 nM; FLT4: 25 nM; JAK1: 19.8 nM; JAK2 (V617F): 0.245 nM (Ki); JAK3: 48.0 nM

Form

Lyophilized powder

Purity

≥98%

Solubility

DMSO: 92 mg/mL (195.76 mM); Water: Insoluble; Ethanol: 9 mg/mL (19.15 mM)

Identity

Confirmed by NMR/HPLC/MS.

Stability

The product is stable for three years when stored at the recommended temperature in lyophilized powder.

Applications

Gandotinib can be utilized to study the inhibition of JAK2 activity in various biological assays.

Storage

Store at -20ºC.