JAK inhibitor Itacitinib, Purity ≥98%

Synonym: Itacitinib; 1334298-90-6; INCB039110; INCB-039110; 2-(3-(4-(7H-Pyrrolo[2,3-d]pyrimidin-4-yl)-1H-pyrazol-1-yl)-1-(1-(3-fluoro-2-(trifluoromethyl)isonicotinoyl)piperidin-4-yl)azetidin-3-yl)acetonitrile; Itacitinib(INCB039110); 2-[1-[1-[3-Fluoro-2-(trifluoromethyl)pyridine-4-carbonyl]piperidin-4-yl]-3-[4-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)pyrazol-1-yl]azetidin-3-yl]acetonitrile; JAK inhibitor

CAS Number: 1334298-90-6
Compound CID: 53380437

Product Size

5 mg; 10 mg; 25 mg; 50 mg; 100 mg

Price

Datasheet

MSDS

Properties

Description

Itacitinib, soluble in DMSO and ethanol and insoluble in water, is an available JAK small molecule inhibitor with potential antineoplastic activity. It targets JAK1.

Molecular Weight

553.51

Molecular Formula

C₂₆H₂₃F₄N₉O

Targets

Form

Lyophilized powder

Purity

Solubility

DMSO: 88 mg/mL (158.98 mM); Water: Insoluble; Ethanol: 88 mg/mL (158.98 mM)

Identity

Confirmed by NMR/HPLC/MS.

Applications

Itacitinib is used to investigate selective inhibition of JAK1-mediated signaling.