JAK inhibitor Itacitinib, Purity ≥98%

Synonym: Itacitinib; 1334298-90-6; INCB039110; INCB-039110; 2-(3-(4-(7H-Pyrrolo[2,3-d]pyrimidin-4-yl)-1H-pyrazol-1-yl)-1-(1-(3-fluoro-2-(trifluoromethyl)isonicotinoyl)piperidin-4-yl)azetidin-3-yl)acetonitrile; Itacitinib(INCB039110); 2-[1-[1-[3-Fluoro-2-(trifluoromethyl)pyridine-4-carbonyl]piperidin-4-yl]-3-[4-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)pyrazol-1-yl]azetidin-3-yl]acetonitrile; JAK inhibitor

CAS Number: 1334298-90-6
Compound CID: 53380437

Product Size

5 mg; 10 mg; 25 mg; 50 mg; 100 mg

Price

Datasheet

Datasheet

MSDS

MSDS

Properties

Description

Itacitinib, soluble in DMSO and ethanol and insoluble in water, is an available JAK small molecule inhibitor with potential antineoplastic activity. It targets JAK1.

Molecular Weight

553.51

Molecular Formula

C₂₆H₂₃F₄N₉O

Targets

JAK1

Form

Lyophilized powder

Purity

≥98%

Solubility

DMSO: 88 mg/mL (158.98 mM); Water: Insoluble; Ethanol: 88 mg/mL (158.98 mM)

Identity

Confirmed by NMR/HPLC/MS.

Stability

The product is stable for three years when stored at the recommended temperature in lyophilized powder.

Applications

Itacitinib is used to investigate selective inhibition of JAK1-mediated signaling.

Storage

Store at -20ºC.