JAK inhibitor JAK/HDAC-IN-1, Purity ≥98%

Synonym: 2284621-75-4; JAK/HDAC-IN-1; 6-(4-((5-Chloro-4-((4-chlorophenyl)amino)pyrimidin-2-yl)amino)-1H-pyrazol-1-yl)-N-hydroxyhexanamide; MUN21754; 6-[4-[[5-Chloro-4-(4-chloroanilino)pyrimidin-2-yl]amino]pyrazol-1-yl]-N-hydroxyhexanamide; JAK inhibitor

MDL: MFCD32062830
CAS Number: 2284621-75-4
Compound CID: 138377596

Product Size

5 mg; 10 mg; 25 mg; 50 mg; 100 mg

Price

Datasheet

Datasheet

MSDS

MSDS

Properties

Description

JAK/HDAC-IN-1 is an available JAK small molecule inhibitor with potential antineoplastic activity. It targets HDAC, HDAC2, HDAC6, HDAC8, JAK1, JAK2, JAK3, and Tyk2.

Molecular Weight

450.32

Molecular Formula

C₁₉H₂₁Cl₂N₇O₂

Targets

HDAC: 2 nM; HDAC2: 14 nM; HDAC6: 120 nM; HDAC8: 2470 nM; JAK1: 4.8 nM; JAK2: 4 nM; JAK3: 7.4 nM; Tyk2: 49 nM

Form

Lyophilized powder

Purity

≥98%

Identity

Confirmed by NMR/HPLC/MS.

Stability

The product is stable for three years when stored at the recommended temperature in lyophilized powder.

Applications

JAK/HDAC-IN-1 is researched for its dual inhibition of JAK kinases and HDACs, particularly in hematological malignancies.

Storage

Store at -20ºC.