JAK inhibitor NVP-BSK805 dihydrochloride, Purity ≥98%

Synonym: NVP-BSK805 2HCl; 1942919-79-0; NVP-BSK805 dihydrochloride; NVP-BSK805 (hydrochloride); NVP-BSK805 (dihydrochloride); BSK805; BSK 805; JAK inhibitor

CAS Number: 1942919-79-0
Compound CID: 57339395

Product Size

5 mg; 10 mg; 25 mg; 50 mg; 100 mg

Price

Datasheet

MSDS

Properties

Description

NVP-BSK805 dihydrochloride, soluble in DMSO, water and ethanol, is an available JAK small molecule inhibitor with potential antineoplastic activity. It targets FL JAK2 wt, JAK1 JH1, JAK2 JH1, JAK2 (V617F), TYK2 JH1, and TYK2 JH1.

Molecular Weight

563.47

Molecular Formula

C₂₇H₃₀Cl₂F₂N₆O

Targets

FL JAK2 wt: 0.58 nM; JAK1 JH1: 31.68 nM; JAK2 JH1: 0.48 nM; JAK2 (V617F): 0.56 nM; TYK2 JH1: 18.68 nM; TYK2 JH1: 10.76 nM

Form

Lyophilized powder

Purity

Solubility

DMSO: 104 mg/mL (184.57 mM); Water: 3 mg/mL (5.32 mM); Ethanol: 14 mg/mL (24.85 mM)

Identity

Confirmed by NMR/HPLC/MS.

Applications

NVP-BSK805 dihydrochloride can be utilized to study selective inhibition of JAK2 kinase function.