JAK inhibitor Pyridone 6, Purity ≥98%

Synonym: Pyridone 6; 457081-03-7; JAK Inhibitor I; Merck-5; CMP 6; Merck 5; CMP-6; JAK inhibitor

MDL: MFCD17019334
CAS Number: 457081-03-7
Compound CID: 5494425

Product Size

5 mg; 10 mg; 25 mg; 50 mg; 100 mg

Price

Datasheet

Datasheet

MSDS

MSDS

Properties

Description

Pyridone 6 is an available JAK small molecule inhibitor with potential antineoplastic activity. It targets cAMP-dependent kinase, CDK2, Csk, FGFR, FGFR2, Flt-1, Flt-4, Fyn T, Hck, IκB kinase 2, and JAK2.

Molecular Weight

309.3

Molecular Formula

C₁₈H₁₆FN₃O

Targets

cAMP-dependent kinase: 7.1 μM; CDK2: 3.3 μM; Csk: 2.1 μM; FGFR: 1.48 μM; FGFR2: 0.94 μM; Flt-1: 1.52 μM; Flt-4: 0.69 μM; Fyn T: 0.5 μM; Hck: 7.7 μM; IκB kinase 2: 0.3 μM; JAK2: 1 nM

Form

Lyophilized powder

Purity

≥98%

Identity

Confirmed by NMR/HPLC/MS.

Stability

The product is stable for three years when stored at the recommended temperature in lyophilized powder.

Applications

Pyridone 6 can be employed to examine the inhibition of JAK kinases and related signaling pathways.

Storage

Store at -20ºC.