JAK inhibitor Ruxolitinib phosphate, Purity ≥98%

Synonym: Ruxolitinib phosphate; 1092939-17-7; Jakafi; Jakavi; (R)-3-(4-(7H-Pyrrolo[2,3-d]pyrimidin-4-yl)-1H-pyrazol-1-yl)-3-cyclopentylpropanenitrile phosphate; OPZELURA; Ruxolitinib (phosphate); JAK inhibitor

MDL: MFCD18452860
CAS Number: 1092939-17-7
Compound CID: 25127112

Product Size

5 mg; 10 mg; 25 mg; 50 mg; 100 mg

Price

Datasheet

Datasheet

MSDS

MSDS

Properties

Description

Ruxolitinib phosphate, soluble in DMSO, water and ethanol, is an available JAK small molecule inhibitor with potential antineoplastic activity. It targets JAK1, JAK2, JAK3, and Tyk2.

Molecular Weight

404.37

Molecular Formula

C₁₇H₂₁N₆O₄P

Targets

JAK1: 3.3 nM; JAK2: 2.8 nM; JAK3: 428 nM; Tyk2: 19 nM

Form

Lyophilized powder

Purity

≥98%

Solubility

DMSO: 73 mg/mL (180.53 mM); Water: 26 mg/mL (64.29 mM); Ethanol: 7 mg/mL (17.31 mM)

Identity

Confirmed by NMR/HPLC/MS.

Stability

The product is stable for three years when stored at the recommended temperature in lyophilized powder.

Applications

Ruxolitinib phosphate is used to study JAK1 and JAK2 selective inhibition.

Storage

Store at -20ºC.