Properties
Description
Ruxolitinib, soluble in DMSO and ethanol and insoluble in water, is an available JAK small molecule inhibitor with potential antineoplastic activity. It targets JAK1, JAK2, JAK3, and Tyk2.
Molecular Formula
C17H18N6
Targets
JAK1: 3.3 nM; JAK2: 2.8 nM; JAK3: 428 nM; Tyk2: 19 nM
Solubility
DMSO: 59 mg/mL (192.57 mM); Water: Insoluble; Ethanol: 59 mg/mL (192.57 mM)
Identity
Confirmed by NMR/HPLC/MS.
Stability
The product is stable for three years when stored at the recommended temperature in lyophilized powder.
Applications
Ruxolitinib can be applied to research associated with the inhibition of JAK1 and JAK2 signaling.