JAK inhibitor S-Ruxolitinib, Purity ≥98%

Synonym: S-Ruxolitinib; 941685-37-6; S-Ruxolitinib (INCB018424); Ruxolitinib (S enantiomer); Ruxolitinib S enantiomer; (3S)-3-Cyclopentyl-3-[4-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)-1H-pyrazol-1-yl]propanenitrile; JAK inhibitor

CAS Number: 941685-37-6
Compound CID: 50878566

Product Size

5 mg; 10 mg; 25 mg; 50 mg; 100 mg

Price

Datasheet

MSDS

Properties

Description

S-Ruxolitinib, soluble in DMSO, water and ethanol, is an available JAK small molecule inhibitor with potential antineoplastic activity. It targets JAK1, TYK2, c-Met, Chk2, JAK2, and JAK3.

Molecular Weight

306.37

Molecular Formula

C₁₇H₁₈N₆

Targets

JAK1: 3.3 nM; TYK2: 19 nM; c-Met: >10 μM; Chk2: >1 μM; JAK2: 2.8 nM; JAK3: 428 nM

Form

Lyophilized powder

Purity

Solubility

DMSO: 59 mg/mL (192.57 mM); Water: 5 mg/mL (16.32 mM); Ethanol: 59 mg/mL (192.57 mM)

Identity

Confirmed by NMR/HPLC/MS.

Applications

S-Ruxolitinib can be utilized to investigate the stereospecific inhibition of JAK1 and JAK2.