JAK inhibitor TCS 21311, Purity ≥98%

Synonym: TCS 21311; 1260181-14-3; NIBR3049; 3-[5-[4-(2-Hydroxy-2-methyl-1-oxopropyl)-1-piperazinyl]-2-(trifluoromethyl)phenyl]-4-(1H-indol-3-yl)-1H-pyrrole-2,5-dione; TCS-21311; CLGRAWDGLMENOD-UHFFFAOYSA-N; JAK inhibitor

CAS Number: 1260181-14-3
Compound CID: 50925411

Product Size

10 mg; 25 mg; 50 mg; 100 mg

Price

Datasheet

Datasheet

MSDS

MSDS

Properties

Description

TCS 21311 is an available JAK small molecule inhibitor with potential antineoplastic activity. It targets GSK-3β, JAK1, JAK2, JAK3, PKCα, and PKCθ.

Molecular Weight

526.51

Molecular Formula

C₂₇H₂₅F₃N₄O₄

Targets

GSK-3β: 3 nM; JAK1: 1.017 μM; JAK2: 2.55 μM; JAK3: 8 nM; PKCα: 13 nM; PKCθ: 68 nM

Form

Lyophilized powder

Purity

≥98%

Identity

Confirmed by NMR/HPLC/MS.

Stability

The product is stable for three years when stored at the recommended temperature in lyophilized powder.

Applications

TCS 21311 can be used to explore the inhibition of Tyk2 and JAK1/2 kinase activity in autoimmune and inflammatory conditions.

Storage

Store at -20ºC.