JAK inhibitor TCS 21311, Purity ≥98%

Synonym: TCS 21311; 1260181-14-3; NIBR3049; 3-[5-[4-(2-Hydroxy-2-methyl-1-oxopropyl)-1-piperazinyl]-2-(trifluoromethyl)phenyl]-4-(1H-indol-3-yl)-1H-pyrrole-2,5-dione; TCS-21311; CLGRAWDGLMENOD-UHFFFAOYSA-N; JAK inhibitor

CAS Number: 1260181-14-3
Compound CID: 50925411

Product Size

10 mg; 25 mg; 50 mg; 100 mg

Price

Datasheet

MSDS

Properties

Description

TCS 21311 is an available JAK small molecule inhibitor with potential antineoplastic activity. It targets GSK-3β, JAK1, JAK2, JAK3, PKCα, and PKCθ.

Molecular Weight

526.51

Molecular Formula

C₂₇H₂₅F₃N₄O₄

Targets

GSK-3β: 3 nM; JAK1: 1.017 μM; JAK2: 2.55 μM; JAK3: 8 nM; PKCα: 13 nM; PKCθ: 68 nM

Form

Lyophilized powder

Purity

Identity

Confirmed by NMR/HPLC/MS.

Applications

TCS 21311 can be used to explore the inhibition of Tyk2 and JAK1/2 kinase activity in autoimmune and inflammatory conditions.