JNK-c-Jun inhibitor IQ-1S, Purity ≥98%

Synonym: IQ-1S; 23146-22-7; IQ-1S free acid; 11H-indeno[1,2-b]quinoxalin-11-one oxime; IQ-1S (free acid); 11-nitroso-10H-indeno[1,2-b]quinoxaline; JNK-c-Jun inhibitor

MDL: MFCD00612483
CAS Number: 23146-22-7
Compound CID: 619002

Product Size

10 mg; 25 mg; 50 mg; 100 mg

Price

Datasheet

Datasheet

MSDS

MSDS

Properties

Description

IQ-1S, soluble in DMSO and ethanol and insoluble in water, is an inhibitor of c-jun N-terminal kinase (JNK) signaling. It targets CK1δ, JNK1, JNK2 and JNK3.

Molecular Weight

247.25

Molecular Formula

C₁₅H₉N₃O

Targets

CK1δ: 0.38 μM (Kd); JNK1: 240 nM (Kd); JNK2: 360 nM (Kd); JNK3: 100 nM (Kd)

Form

Lyophilized powder

Purity

≥98%

Solubility

DMSO: 45 mg/mL (181.99 mM); Water: Insoluble; Ethanol: 1 mg/mL (4.04 mM)

Identity

Confirmed by NMR/HPLC/MS.

Stability

The product is stable for three years when stored at the recommended temperature in lyophilized powder.

Applications

IQ-1S can be applied to study domain-specific inhibition of GP130/IGF signaling in cancer research.

Storage

Store at -20ºC.