JNK-c-Jun inhibitor SP600125, Purity ≥98%

Synonym: 129-56-6; 1,9-Pyrazoloanthrone; SP600125; Pyrazolanthrone; Dibenzo[cd,g]indazol-6(2H)-one; Pyrazoleanthrone; JNK-c-Jun inhibitor

MDL: MFCD00022289
CAS Number: 129-56-6
Compound CID: 8515

Product Size

10 mg; 25 mg; 50 mg; 100 mg; 200 mg

Price

Datasheet

Datasheet

MSDS

MSDS

Properties

Description

SP600125, soluble in DMSO and insoluble in ethanol and water, is an inhibitor of c-jun N-terminal kinase (JNK) signaling. It targets Aurora A, Chk1, EGF, and ERK2.

Molecular Weight

220.2

Molecular Formula

C₁₄H₈N₂O

Targets

Aurora A: 60 nM; Chk1: >10 μM; EGF: >10 μM; ERK2: >10 μM

Form

Lyophilized powder

Purity

≥98%

Solubility

DMSO: 43 mg/mL (195.25 mM); Water: Insoluble; Ethanol: Insoluble

Identity

Confirmed by NMR/HPLC/MS.

Stability

The product is stable for three years when stored at the recommended temperature in lyophilized powder.

Applications

SP600125 is utilized to study the inhibition of JNK (c-Jun N-terminal kinase) and its effects on apoptosis, inflammation, and cancer.

Storage

Store at -20ºC.