Properties
Description
Ketanserin (vulketan gel), soluble in DMSO and insoluble in water and ethanol, inhibits the signaling pathway between G-protein-coupled receptors (GPCRs) and G proteins. It targets 5-HT2A, 5-HT2C (human), and 5-HT2C (rat).
Molecular Formula
C22H22FN3O3
Targets
5-HT2A: 2.5 nM (Ki); 5-HT2C (Human): 100 nM (Ki); 5-HT2C (Rat): 50 nM (Ki)
Solubility
DMSO: 2 mg/mL (5.05 mM); Water: insoluble; Ethanol: insoluble
Stability
The product is stable for three years when stored at the recommended temperature in lyophilized powder.
Applications
Ketanserin (vulketan gel) can be used as a selective serotonin receptor antagonist (specifically targeting the 5-HT2A receptor subtype), leading to vasodilation and lowering of blood pressure.
Storage
Store at -20℃, and keep desiccated.
