Kinesin inhibitor, GSK-923295, Purity ≥98%

Synonym: 1088965-37-0; GSK923295; GSK 923295; 3-Chloro-N-[(2S)-1-[[2-(dimethylamino)acetyl]amino]-3-[4-[8-[(1S)-1-hydroxyethyl]imidazo[1,2-a]pyridin-2-yl]phenyl]propan-2-yl]-4-propan-2-yloxybenzamide

MDL: MFCD16038931
CAS Number: 1088965-37-0
Compound CID: 46898058

Product Size

5 mg; 10 mg; 25 mg; 50 mg

Price

Datasheet

Datasheet

MSDS

MSDS

Properties

Description

GSK-923295, soluble in DMSO and ethanol and insoluble in water, is an effective cytoskeleton inhibitor, that has the ability to prevent the pathway of cytoskeletal signaling by inhibiting kinesin. It targets the CENP-E.

Molecular Weight

592.13

Molecular Formula

C₃₂H₃₈ClN₅O₄

Targets

CENP-E: 3.2 nM (Ki)

Form

Lyophilized powder

Purity

≥98%

Titer

Free from inappropriate visible particulates, foreign matter, discoloration, or other defects

Solubility

In vitro: DMSO: 90 mg/mL (151.99 mM); Water: insoluble; Ethanol: 90 mg/mL (151.99 mM)

Applications

GSK-923295 is a cytoskeletal signaling inhibitor that plays a key role in cancer research to disrupt mitotic spindle formation, leading to cell cycle arrest and apoptosis in cancer cells.