Properties
Description
K 858, soluble in DMSO and ethanol and insoluble in water, is an effective cytoskeleton inhibitor, that has the ability to prevent the pathway of cytoskeletal signaling by inhibiting kinesin. It targets the Eg5.
Molecular Formula
C13H15N3O2S
Targets
Eg5: 1.3 μM (IC50)
Titer
Free from inappropriate visible particulates, foreign matter, discoloration, or other defects
Solubility
In vitro: DMSO: 53 mg/mL (191.1 mM); Water: insoluble; Ethanol: 4 mg/mL (14.42 mM)
Stability
In its lyophilized form, the chemical remains stable for 36 months.
Quality Level
Research grade
Applications
K 858 is a cytoskeletal signaling inhibitor that plays a key role in disrupting mitotic spindle formation, which can lead to cancer cell death.
Storage
Store at -20ºC, and keep desiccated.
