Kinesin inhibitor, SB 743921, Purity ≥98%

Synonym: 940929-33-9; SB-743921; SB743921; SB-743921 hydrochloride; N-(3-Aminopropyl)-N-[(1R)-1-(3-benzyl-7-chloro-4-oxochromen-2-yl)-2-methylpropyl]-4-methylbenzamide; hydrochloride

CAS Number: 940929-33-9
Compound CID: 49867937

Product Size

5 mg; 10 mg; 50 mg; 100 mg

Price

Datasheet

Datasheet

MSDS

MSDS

Properties

Description

SB 743921, soluble in DMSO, water and ethanol, is an effective cytoskeleton inhibitor, that has the ability to prevent the pathway of cytoskeletal signaling by inhibiting kinesin. It targets the KSP, KSP(Colo205cells), KSP(MV522cells), and KSP(MX1cells).

Molecular Weight

553.5

Molecular Formula

C₃₁H₃₃N₂O₃·HCl

Targets

KSP: 0.1nM; KSP (Colo205cells): 0.07nM; KSP (MV522cells): 1.7nM; KSP (MX1cells): 0.06nM

Form

Lyophilized powder

Purity

≥98%

Titer

Free from inappropriate visible particulates, foreign matter, discoloration, or other defects

Solubility

In vitro: DMSO: 103 mg/mL (186.08 mM); Water: 20 mg/mL (36.13 mM); Ethanol: 103 mg/mL (186.08 mM); In vivo: Saline pH 5.0, 28 mg/mL

Applications

SB 743921 is a cytoskeletal signaling inhibitor that displays the significant potential to act as an effective anti-cancer agent due to its role in disrupting cell division and reducing tumor growth.