Properties
Description
BMS-5, soluble in DMSO and ethanol and insoluble in water, targets LIM kinases, which regulate actin cytoskeleton dynamics and are involved in cell migration and cancer metastasis. It targets LIMK1 and LIMK2.
Molecular Formula
C17H14Cl2F2N4OS
Targets
LIMK1: 7 nM; LIMK2: 8 nM
Solubility
DMSO: 75 mg/mL (173.9 mM); Water: Insoluble; Ethanol: 4 mg/mL (9.27 mM)
Identity
Confirmed by NMR/HPLC/MS.
Applications
BMS-5 can be used to inhibit the LIM kinase dihydrochloride signaling and study neuronal and cancer cell functions.
