Unveiling the Complexities of Low-substituted Hydroxypropyl Cellulose (L-HPC) -Analysis at Your Service

L-HPC is a nonionic cellulose ether obtained by reacting alkaline cellulose with propylene oxide under high-temperature pressure, which is a non-toxic and nonirritating excipient. Since its powder has a large surface area and porosity, it can be used as a disintegrant and binder for solid formulations. In addition, due to its rough structure with a large mosaic between the drug particles, it can significantly increase the hardness of tablets and accelerate the dissolution of drugs.

CD BioGlyco provides high-quality L-HPC analysis service to every client with best-in-class Pharmaceutical Excipient Analysis technology.

• Identification
  • A suitable amount of anthrone sulfate solution is added to a suspension of the sample with water, this sample is L-HPC if a blue-green color appears at the junction of the liquid levels.
  • After adding sodium hydroxide and acetone-methanol mixture to the sample in turn, if a white flocculent precipitate appears, then this sample is L-HPC.
• Solubility
  L-HPC is insoluble in water, which it dissolves into a colloidal solution. L-HPC is also insoluble in ethanol, acetone, or ether, but soluble in 10% sodium hydroxide solution.
• pH
  L-HPC is acidic, with a pH between 5.0 and 7.5.
• Hydroxypropyl content
  The hydroxypropyl content of L-HPC is specified as 7.0% to 16.0%.
  • Gas chromatography: Phenyl-methyl-polysiloxane is used as a stationary solution to determine the hydroxypropyl content of L-HPC. In this process, the peak area of the spectrum is calculated by the internal standard method after the L-HPC sample is injected into the chromatography.
  • Titration: Firstly, under a high-temperature environment, we distill the prepared sample solution and collect the specific fractions. Then, with sodium hydroxide solution and sodium thiosulfate solution as titrant, we perform two stages of titration experiments on them respectively and record the amount of titrant used at the same time. Finally, the content of hydroxypropyl in L-HPC is calculated based on the amount of titrant used.
• Chloride assay
  Add an appropriate amount of silver nitrate solution into L-HPC and standard sodium chloride solution respectively, observe the changes of the two solutions, and compare them. If the phenomena are the same, it is proved that L-HPC contains chloride.
• Arsenic salt assay
  Calcium hydroxide is added to the L-HPC sample and heated until charred, then incandescent at 500-600°C for complete ashing, then hydrochloric acid is added to it. Finally, the sample is tested for the presence of arsenic spots.
• Loss on drying
  L-HPC is dried at high temperature for several hours. The weight loss should not exceed 5.0%.
• Scorch residue
  L-HPC is fully cauterized, leaving a residue of not more than 1.0%.

Publication Data

Frequently Asked Questions

• What are the uses of L-HPC?
  • L-HPC is easily pressed and molded and is highly applicable. When tablets are added with L-HPC, it not only improves their hardness and appearance of brightness but also makes the tablets disintegrate rapidly and improves the therapeutic effect.
  • L-HPC can also be used as a food additive. It is used as an emulsifier, stabilizer, suspending agent, thickening agent, and film-forming agent in the food industry, and used in the manufacture of beverages, pastry, and jam.
  • L-HPC is also used in the daily chemical industry as cream, shampoo, emulsion, and other cosmetics.
• What is the essential difference between L-HPC and highly substituted hydroxypropyl cellulose (H-HPC)?
  Hydroxypropyl cellulose is a non-ionic cellulose ether obtained by reacting alkaline cellulose with propylene oxide under high temperature and high pressure, and it is divided into L-HPC and H-HPC according to the difference in hydroxypropyl content of its substituent group. The hydroxypropyl content of L-HPC is stipulated to be 7.0%-16.0%, while the substitution of H-HPC is higher, but the amount of its hydroxypropyl shall not exceed 80.5%.

Advantages

• Our powerful Pharmaceutical and Biological Analysis platform provides clients with multiple perspectives of L-HPC analysis, such as physicochemical property analysis and biological activity analysis.
• We not only provide one-on-one custom L-HPC analysis service to our clients but also provide detailed report interpretation.
• We provide a good customer service experience, communicate closely with our clients, adjust the L-HPC analysis plan according to their needs, and ensure the quality and accuracy of the service process.

CD BioGlyco provides high-quality, custom L-HPC analysis services based on advanced analysis technologies. We are committed to helping our clients efficiently solve the challenges they encounter in their research. Please feel free to contact us if you are interested in our services.