LRRK2 inhibitor, GNE-7915, Purity ≥98%

Synonym: 1351761-44-8; GNE7915; GMS 7915; [4-[[4-(Ethylamino)-5-(trifluoromethyl)pyrimidin-2-yl]amino]-2-fluoro-5-methoxyphenyl]-morpholin-4-ylmethanone; LRRK2 inhibitor

MDL: MFCD25977005
CAS Number: 1351761-44-8
Compound CID: 58539171

Product Size

10 mg; 25 mg; 50 mg; 100 mg

Price

Datasheet

Datasheet

MSDS

MSDS

Properties

Description

GNE-7915, soluble in DMSO and insoluble in water and ethanol, is an effective autophagy signaling inhibitor, that has the ability to prevent the pathway of autophagy signaling by inhibiting LRRK2. The molecular weight of the compound is 443.395, and its molecular formula is C₁₉H₂₁F₄N₅O₃. It targets the LRRK2 and LRRK2.

Molecular Weight

443.395

Molecular Formula

C₁₉H₂₁F₄N₅O₃

Targets

LRRK2

Form

Lyophilized powder

Purity

≥98%

Impurities

Free from inappropriate visible particulates, foreign matter, discoloration, or other defects.

Solubility

In vitro: DMSO (warmed): 21 mg/mL (47.36 mM); Water: insoluble; Ethanol: insoluble; In vivo: 5% DMSO + 30% PEG 300 + 5% Tween 80 + ddH₂O 2.9 mg/mL

Identity

Confirmed by NMR/HPLC/MS.

Applications

GNE-7915 can be used for its ability to ameliorate Parkinson’s disease symptoms by inhibiting the toxic effects of LRRK2 mutations.