LRRK2 inhibitor, LRRK2-IN-1, Purity ≥98%

Synonym: 1234480-84-2; LRRK2IN1; LRRK2-IN1; 2-[2-Methoxy-4-[4-(4-methylpiperazin-1-yl)piperidine-1-carbonyl]anilino]-5,11-dimethylpyrimido[4,5-b][1,4]benzodiazepin-6-one; LRRK2 inhibitor

CAS Number: 1234480-84-2
Compound CID: 46843906

Product Size

10 mg; 25 mg; 50 mg; 100 mg

Price

Datasheet

Datasheet

MSDS

MSDS

Properties

Description

LRRK2-IN-1, soluble in DMSO and ethanol and insoluble in water, is an effective autophagy signaling inhibitor, that has the ability to prevent the pathway of autophagy signaling by inhibiting LRRK2. The molecular weight of the compound is 570.09, and its molecular formula is C₃₁H₃₈N₈O₃. It targets the LRRK2(G2019S), LRRK2(WT), DCLK1 and DCLK2.

Molecular Weight

570.09

Molecular Formula

C₃₁H₃₈N₈O₃

Targets

LRRK2 (G2019S)

Form

Lyophilized powder

Purity

≥98%

Impurities

Free from inappropriate visible particulates, foreign matter, discoloration, or other defects.

Solubility

In vitro: DMSO: 97 mg/mL (169.96 mM); Water: insoluble; Ethanol: 97 mg/mL (169.96 mM); In vivo: Captisol, 16 mg/mL

Identity

Confirmed by NMR/HPLC/MS.

Applications

LRRK2-IN-1 can be studied extensively for its potential therapeutic applications in the treatment of Parkinson’s by reducing LRRK2 activity, which may help in mitigating neurodegeneration.