Properties
Description
LXS196, soluble in DMSO and ethanol and insoluble in water, blocks the function of Smad proteins in the TGF-β signaling pathway. It targets GSK3β, PKCα, and PKCθ.
Molecular Formula
C22H23F3N8O
Targets
GSK3β: 3.1 μM; PKCα: 1.9 nM; PKCθ: 0.4 nM
Solubility
DMSO: 20 mg/mL (42.33 mM); Water: insoluble; Ethanol: 5 mg/mL (10.58 mM)
Applications
LXS196 can be used as a novel approach for managing various types of pain, including neuropathic pain and inflammatory pain.
