Properties
Description
LY 344864 hydrochloride inhibits the signaling pathway between G-protein-coupled receptors (GPCRs) and G proteins. It targets human 5-HT1A receptor, human 5-HT1B receptor, human 5-HT1D receptor, human 5-HT1E receptor, human 5-HT1F receptor, human 5-HT2A receptor, human 5-HT2B receptor, human 5-HT3A receptor, human 5-HT7 receptor, rat α1-adrenergic receptor, and rat α2-adrenergic receptor.
Molecular Formula
C21H23ClFN3O
Targets
Human 5-HT1A receptor: 0.530 μM; Human 5-HT1B receptor: 0.549 μM; Human 5-HT1D receptor: 0.575 μM; Human 5-HT1E receptor: 1.415 μM; Human 5-HT1F receptor: 0.006 μM; Human 5-HT2A receptor: 3.499 μM; Human 5-HT2B receptor: 1.695 μM; Human 5-HT3A receptor: 3.935 mM; Human 5-HT7 receptor: 4.851 μM; Rat α1-adrenergic receptor: 5.06 μM; Rat α2-adrenergic receptor: 3.69 μM
Stability
The product is stable for three years when stored at the recommended temperature in lyophilized powder.
Applications
LY 344864 hydrochloride can be used to research and develop therapeutic strategies for certain diseases that involve excessive activation of GPCR-G protein signaling pathways.
Storage
Store at -20°C, and keep desiccated.
