LY 344864

Synonym: 186544-26-3; (R)-N-(3-(Dimethylamino)-2,3,4,9-tetrahydro-1H-carbazol-6-yl)-4-fluorobenzamide hydrochloride

CAS Number: 186544-26-3
Compound CID: 56972176

Product Size

5 mg; 10 mg; 50 mg; 100 mg

Price

Datasheet

MSDS

Properties

Description

LY 344864, soluble in DMSO and water, and insoluble in ethanol, inhibits the signaling pathway between G-protein-coupled receptors (GPCRs) and G proteins. It targets human 5-HT1A receptor, human 5-HT1B receptor, human 5-HT1D receptor, human 5-HT1E receptor, human 5-HT1F receptor, human 5-HT2A receptor, human 5-HT2B receptor, human 5-HT3A receptor, human 5-HT7 receptor, rat α1-adrenergic receptor, and rat α2-adrenergic receptor.

Molecular Weight

351.42

Molecular Formula

C₂₁H₂₂FN₃O

Targets

Human 5-HT1A receptor: 0.530 μM; Human 5-HT1B receptor: 0.549 μM; Human 5-HT1D receptor: 0.575 μM; Human 5-HT1E receptor: 1.415 μM; Human 5-HT1F receptor: 0.006 μM; Human 5-HT2A receptor: 3.499 μM; Human 5-HT2B receptor: 1.695 μM; Human 5-HT3A receptor: 3.935 mM; Human 5-HT7 receptor: 4.851 μM; Rat α1-adrenergic receptor: 5.06 μM; Rat α2-adrenergic receptor: 3.69 μM

Form

Lyophilized powder

Purity

Solubility

DMSO: 61 mg/mL; Water: 14 mg/mL; Ethanol: insoluble

Applications

LY 344864 can be used for its ability to cross the blood brain barrier to some extent.