LY 344864

Synonym: 186544-26-3; (R)-N-(3-(Dimethylamino)-2,3,4,9-tetrahydro-1H-carbazol-6-yl)-4-fluorobenzamide hydrochloride

CAS Number: 186544-26-3
Compound CID: 56972176

Product Size

5 mg; 10 mg; 50 mg; 100 mg

Price

Datasheet

Datasheet

MSDS

MSDS

Properties

Description

LY 344864, soluble in DMSO and water, and insoluble in ethanol, inhibits the signaling pathway between G-protein-coupled receptors (GPCRs) and G proteins. It targets human 5-HT1A receptor, human 5-HT1B receptor, human 5-HT1D receptor, human 5-HT1E receptor, human 5-HT1F receptor, human 5-HT2A receptor, human 5-HT2B receptor, human 5-HT3A receptor, human 5-HT7 receptor, rat α1-adrenergic receptor, and rat α2-adrenergic receptor.

Molecular Weight

351.42

Molecular Formula

C₂₁H₂₂FN₃O

Targets

Human 5-HT1A receptor: 0.530 μM; Human 5-HT1B receptor: 0.549 μM; Human 5-HT1D receptor: 0.575 μM; Human 5-HT1E receptor: 1.415 μM; Human 5-HT1F receptor: 0.006 μM; Human 5-HT2A receptor: 3.499 μM; Human 5-HT2B receptor: 1.695 μM; Human 5-HT3A receptor: 3.935 mM; Human 5-HT7 receptor: 4.851 μM; Rat α1-adrenergic receptor: 5.06 μM; Rat α2-adrenergic receptor: 3.69 μM

Form

Lyophilized powder

Purity

>98%

Solubility

DMSO: 61 mg/mL; Water: 14 mg/mL; Ethanol: insoluble

Stability

The product is stable for three years when stored at the recommended temperature in lyophilized powder.

Applications

LY 344864 can be used for its ability to cross the blood brain barrier to some extent.

Storage

Store at -20°C, and keep desiccated.