LY364947

Synonym: 396129-53-6; HTS 466284; TGF-β RI Kinase Inhibitor; 4-(3-(Pyridin-2-yl)-1H-pyrazol-4-yl)quinoline

CAS Number: 396129-53-6
PubChem CID: 447966

Product Size

10 mg; 25 mg; 50 mg; 100 mg

Price

Datasheet

Datasheet

MSDS

MSDS

Properties

Description

LY364947, soluble in DMSO and insoluble in water and ethanol, blocks the function of Smad proteins in the TGF-β signaling pathway. It targets CK1δ (cell-free assay), MLK-7K (cell-free assay), RIPK2 (cell-free assay), TGFβRI (cell-free assay), and TGFβRII (cell-free assay).

Molecular Weight

272.3

Molecular Formula

C₁₇H₁₂N₄

Targets

CK1δ (Cell-free assay): 0.22 μM; MLK-7K (Cell-free assay): 1.4 μM; RIPK2 (Cell-free assay): 0.11 μM; TGFβRI (Cell-free assay): 59 nM; TGFβRII (Cell-free assay): 0.4 μM

Form

Lyophilized powder

Purity

>98%

Solubility

DMSO: 1 mg/mL (3.67 mM); Water: insoluble; Ethanol: insoluble

Applications

LY364947 can be used as a pharmacological tool to investigate the role of mGluR1 in various neurobiological processes.