Macitentan

Synonym: 441798-33-0; Opsumit; ACT-064992; Actelion-1

CAS Number: 441798-33-0
Compound CID: 16004692

Product Size

5 mg; 10 mg; 20 mg; 50 mg

Price

Datasheet

Datasheet

MSDS

MSDS

Properties

Description

Macitentan, soluble in DMSO and insoluble in water and ethanol, inhibits the signaling pathway between G-protein-coupled receptors (GPCRs) and G proteins. It targets ET-A, and ET-B.

Molecular Weight

588.27

Molecular Formula

C₁₉H₂₀Br₂N₆O₄S

Targets

ET-A: 0.5 nM; ET-B: 391 nM

Form

Lyophilized powder

Purity

>98%

Solubility

DMSO: 87 mg/mL (147.88 mM); Water: insoluble; Ethanol: insoluble

Applications

Macitentan can be used for its effect on blocking the effects of endothelin, which helps to relax the blood vessels and improve blood flow in the lungs.