Properties
Description
Macitentan, soluble in DMSO and insoluble in water and ethanol, inhibits the signaling pathway between G-protein-coupled receptors (GPCRs) and G proteins. It targets ET-A, and ET-B.
Molecular Formula
C19H20Br2N6O4S
Targets
ET-A: 0.5 nM; ET-B: 391 nM
Solubility
DMSO: 87 mg/mL (147.88 mM); Water: insoluble; Ethanol: insoluble
Stability
The product is stable for three years when stored at the recommended temperature in lyophilized powder.
Applications
Macitentan can be used for its effect on blocking the effects of endothelin, which helps to relax the blood vessels and improve blood flow in the lungs.
Storage
Store at -20°C, and keep desiccated.
