MDM2 antagonist Nutlin-3, Purity ≥98%

Synonym: 548472-68-0; 890090-75-2; Nutlin-3; Nutlin 3; (Rac)-Nutlin-3; 4-(4,5-Bis(4-chlorophenyl)-2-(2-isopropoxy-4-methoxyphenyl)-4,5-dihydro-1H-imidazole-1-carbonyl)piperazin-2-one; MDM2 antagonist

MDL: MFCD14636430; MFCD07784509; MFCD11977784
CAS Number: 548472-68-0
Compound CID: 216345

Product Size

5 mg; 10 mg; 25 mg; 50 mg; 100 mg

Price

Datasheet

Datasheet

MSDS

MSDS

Properties

Description

Nutlin-3, soluble in DMSO and ethanol and insoluble in water, is an active small molecule compound that mediates the MDM2 signaling pathway.

Molecular Weight

581.5

Molecular Formula

C₃₀H₃₀Cl₂N₄O₄

Form

Lyophilized powder

Purity

≥98%

Solubility

DMSO: 87 mg/mL (149.61 mM); Water: Insoluble; Ethanol: 26 mg/mL (44.71 mM)

Identity

Confirmed by NMR/HPLC/MS.

Stability

The product is stable for three years when stored at the recommended temperature in lyophilized powder.

Applications

Nutlin-3 is studied for its ability to inhibit the interaction between p53 and MDM2, thereby stabilizing p53 and inducing apoptosis in cancer cells.

Storage

Store at -20ºC.