Cat. No.: X23-10-ZQ141
MDM2 degrader MD-224, Purity ≥98%
Synonym: 2136247-12-4; MD-224; EX-A3426; (3'R,4'S,5'R)-6''-Chloro-4'-(3-chloro-2-fluorophenyl)-N-(4-((5-(2-(2,6-dioxopiperidin-3-yl)-1-oxoisoindolin-4-yl)pent-4-yn-1-yl)carbamoyl)phenyl)-2''-oxodispiro[cyclohexane-1,2'-pyrrolidine-3',3''-indoline]-5'-carboxamide; MDM2 degrader
- CAS Number: 2136247-12-4
- Compound CID: 131986956
Product Size
5 mg; 10 mg; 25 mg; 50 mg; 100 mg
Properties
Description
MD-224 prevents the degradation of p53 by inhibiting the MDM2-p53 interaction, leading to increased p53 levels and promoting apoptosis in p53-responsive cells.
Molecular Formula
C48H43Cl2FN6O6
Identity
Confirmed by NMR/HPLC/MS.
Stability
The product is stable for three years when stored at the recommended temperature in lyophilized powder.
Applications
MD-224 can be used to study the effects of MDM2-p53 interaction inhibition in promoting p53 stabilization and anti-cancer activity.
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