MDM2 inhibitor AMG232, Purity ≥98%

Synonym: 1352066-68-2; KRT-232; AMG-232; Navtemadlin; AMG 232; AMG232; 2-((3R,5R,6S)-5-(3-Chlorophenyl)-6-(4-chlorophenyl)-1-((S)-1-(isopropylsulfonyl)-3-methylbutan-2-yl)-3-methyl-2-oxopiperidin-3-yl)acetic acid; MDM2 inhibitor

CAS Number: 1352066-68-2
Compound CID: 58573469

Product Size

5 mg; 10 mg; 25 mg; 50 mg; 100 mg

Price

Datasheet

Datasheet

MSDS

MSDS

Properties

Description

AMG232 prevents the degradation of p53 by inhibiting the MDM2-p53 interaction, leading to increased p53 levels and promoting apoptosis in p53-responsive cells.

Molecular Weight

568.55

Molecular Formula

C₂₈H₃₅Cl₂NO₅S

Form

Lyophilized powder

Purity

≥98%

Identity

Confirmed by NMR/HPLC/MS.

Stability

The product is stable for three years when stored at the recommended temperature in lyophilized powder.

Applications

AMG232 can be employed to investigate the pharmacological effects of MDM2 inhibition in p53-expressing tumors.

Storage

Store at -20ºC.