MDM2 inhibitor AMG232, Purity ≥98%

Synonym: 1352066-68-2; KRT-232; AMG-232; Navtemadlin; AMG 232; AMG232; 2-((3R,5R,6S)-5-(3-Chlorophenyl)-6-(4-chlorophenyl)-1-((S)-1-(isopropylsulfonyl)-3-methylbutan-2-yl)-3-methyl-2-oxopiperidin-3-yl)acetic acid; MDM2 inhibitor

CAS Number: 1352066-68-2
Compound CID: 58573469

Product Size

5 mg; 10 mg; 25 mg; 50 mg; 100 mg

Price

Datasheet

Datasheet

MSDS

MSDS

Properties

Description

AMG232 prevents the degradation of p53 by inhibiting the MDM2-p53 interaction, leading to increased p53 levels and promoting apoptosis in p53-responsive cells.

Molecular Weight

568.55

Molecular Formula

C₂₈H₃₅Cl₂NO₅S

Form

Lyophilized powder

Purity

≥98%

Identity

Confirmed by NMR/HPLC/MS.

Applications

AMG232 can be employed to investigate the pharmacological effects of MDM2 inhibition in p53-expressing tumors.