MDM2 inhibitor HDM201, Purity ≥98%

Synonym: 1448867-41-1; Siremadlin; HDM-201; HDM201; NVP-HDM 201; NVP-HDM201; Siremadlin [USAN]; (S)-5-(5-Chloro-1-methyl-2-oxo-1,2-dihydropyridin-3-yl)-6-(4-chlorophenyl)-2-(2,4-dimethoxypyrimidin-5-yl)-1-isopropyl-5,6-dihydropyrrolo[3,4-d]imidazol-4(1H)-one; MDM2 inhibitor

CAS Number: 1448867-41-1
Compound CID: 71678098

Product Size

2 mg; 5 mg; 10 mg; 25 mg; 50 mg

Price

Datasheet

Datasheet

MSDS

MSDS

Properties

Description

HDM201, soluble in DMSO and ethanol and insoluble in water, prevents the degradation of p53 by inhibiting the MDM2-p53 interaction, leading to increased p53 levels and promoting apoptosis in p53-responsive cells.

Molecular Weight

555.41

Molecular Formula

C₂₆H₂₄Cl₂N₆O₄

Form

Lyophilized powder

Purity

≥98%

Solubility

DMSO: 98 mg/mL (176.44 mM); Water: Insoluble; Ethanol: 3 mg/mL (5.4 mM)

Identity

Confirmed by NMR/HPLC/MS.

Stability

The product is stable for three years when stored at the recommended temperature in lyophilized powder.

Applications

HDM201 can be studied for its capability to stabilize p53 by preventing HDM2-mediated degradation, potentially useful in cancer therapy.

Storage

Store at -20ºC.