MDM2 inhibitor HDM201, Purity ≥98%

Synonym: 1448867-41-1; Siremadlin; HDM-201; HDM201; NVP-HDM 201; NVP-HDM201; Siremadlin [USAN]; (S)-5-(5-Chloro-1-methyl-2-oxo-1,2-dihydropyridin-3-yl)-6-(4-chlorophenyl)-2-(2,4-dimethoxypyrimidin-5-yl)-1-isopropyl-5,6-dihydropyrrolo[3,4-d]imidazol-4(1H)-one; MDM2 inhibitor

CAS Number: 1448867-41-1
Compound CID: 71678098

Product Size

2 mg; 5 mg; 10 mg; 25 mg; 50 mg

Price

Datasheet

Datasheet

MSDS

MSDS

Properties

Description

HDM201, soluble in DMSO and ethanol and insoluble in water, prevents the degradation of p53 by inhibiting the MDM2-p53 interaction, leading to increased p53 levels and promoting apoptosis in p53-responsive cells.

Molecular Weight

555.41

Molecular Formula

C₂₆H₂₄Cl₂N₆O₄

Form

Lyophilized powder

Purity

≥98%

Solubility

DMSO: 98 mg/mL (176.44 mM); Water: Insoluble; Ethanol: 3 mg/mL (5.4 mM)

Identity

Confirmed by NMR/HPLC/MS.

Applications

HDM201 can be studied for its capability to stabilize p53 by preventing HDM2-mediated degradation, potentially useful in cancer therapy.