MDM2 inhibitor Idasanutlin, Purity ≥98%

Synonym: 1229705-06-9; Idasanutlin; RG7388; RG-7388; Idasanutlin (RG-7388); Idasanutlin (RG7388); RO5503781; 4-((2R,3S,4R,5S)-3-(3-Chloro-2-fluorophenyl)-4-(4-chloro-2-fluorophenyl)-4-cyano-5-neopentylpyrrolidine-2-carboxamido)-3-methoxybenzoic acid; MDM2 inhibitor

MDL: MFCD26142931
CAS Number: 1229705-06-9
Compound CID: 53358942

Product Size

5 mg; 10 mg; 25 mg; 50 mg; 100 mg

Price

Datasheet

Datasheet

MSDS

MSDS

Properties

Description

Idasanutlin, soluble in DMSO and warmed ethanol and insoluble in water, prevents the degradation of p53 by inhibiting the MDM2-p53 interaction, leading to increased p53 levels and promoting apoptosis in p53-responsive cells. It targets Mdm2.

Molecular Weight

616.48

Molecular Formula

C₃₁H₂₉Cl₂F₂N₃O₄

Targets

Mdm2

Form

Lyophilized powder

Purity

≥98%

Solubility

DMSO: 88 mg/mL (142.74 mM); Water: Insoluble; Warmed ethanol: 7 mg/mL (11.35 mM)

Identity

Confirmed by NMR/HPLC/MS.

Stability

The product is stable for three years when stored at the recommended temperature in lyophilized powder.

Applications

Idasanutlin can be utilized in cancer research to inhibit MDM2 and stabilize p53, promoting tumor cell apoptosis.

Storage

Store at -20ºC.