MDM2 inhibitor Idasanutlin, Purity ≥98%

Synonym: 1229705-06-9; Idasanutlin; RG7388; RG-7388; Idasanutlin (RG-7388); Idasanutlin (RG7388); RO5503781; 4-((2R,3S,4R,5S)-3-(3-Chloro-2-fluorophenyl)-4-(4-chloro-2-fluorophenyl)-4-cyano-5-neopentylpyrrolidine-2-carboxamido)-3-methoxybenzoic acid; MDM2 inhibitor

MDL: MFCD26142931
CAS Number: 1229705-06-9
Compound CID: 53358942

Product Size

5 mg; 10 mg; 25 mg; 50 mg; 100 mg

Price

Datasheet

Datasheet

MSDS

MSDS

Properties

Description

Idasanutlin, soluble in DMSO and warmed ethanol and insoluble in water, prevents the degradation of p53 by inhibiting the MDM2-p53 interaction, leading to increased p53 levels and promoting apoptosis in p53-responsive cells. It targets Mdm2.

Molecular Weight

616.48

Molecular Formula

C₃₁H₂₉Cl₂F₂N₃O₄

Targets

Mdm2

Form

Lyophilized powder

Purity

≥98%

Solubility

DMSO: 88 mg/mL (142.74 mM); Water: Insoluble; Warmed ethanol: 7 mg/mL (11.35 mM)

Identity

Confirmed by NMR/HPLC/MS.

Applications

Idasanutlin can be utilized in cancer research to inhibit MDM2 and stabilize p53, promoting tumor cell apoptosis.