MDM2 inhibitor NSC-207895, Purity ≥98%

Synonym: 58131-57-0; NSC 207895; NSC-207895; NSC207895; NSC 179940; 4-(4-Methyl-1-piperazinyl)-7-nitro-benzofurazan 3-oxide; MDM2 inhibitor

CAS Number: 58131-57-0
Compound CID: 42640

Product Size

5 mg; 10 mg; 25 mg; 50 mg; 100 mg

Price

Datasheet

Datasheet

MSDS

MSDS

Properties

Description

NSC-207895, soluble in DMSO and insoluble in ethanol and water, prevents the degradation of p53 by inhibiting the MDM2-p53 interaction, leading to increased p53 levels and promoting apoptosis in p53-responsive cells. It targets p53 and MDMX.

Molecular Weight

279.25

Molecular Formula

C₁₁H₁₃N₅O₄

Targets

p53; MDMX: 2.5 μM

Form

Lyophilized powder

Purity

≥98%

Solubility

DMSO: 0.39 mg/mL (1.39 mM); Water: Insoluble; Ethanol: Insoluble

Identity

Confirmed by NMR/HPLC/MS.

Stability

The product is stable for three years when stored at the recommended temperature in lyophilized powder.

Applications

NSC-207895 can be used to enhance p53 activity by inhibiting MDM2-p53 interactions in cancer cells.

Storage

Store at -20ºC.