MDM2 inhibitor Nutlin 3a, Purity ≥98%

Synonym: 675576-98-4; Nutlin-3A; Nutlin-3; Nutlin 3a; (-)-Nutlin-3; Nutlin-3a chiral; 4-[[(4S,5R)-4,5-Bis(4-chlorophenyl)-4,5-dihydro-2-[4-methoxy-2-(1-methylethoxy)phenyl]-1H-imidazol-1-yl]carbonyl]-2-piperazinone; MDM2 inhibitor

MDL: MFCD14636430
CAS Number: 675576-98-4
Compound CID: 11433190

Product Size

5 mg; 10 mg; 25 mg; 50 mg; 100 mg

Price

Datasheet

Datasheet

MSDS

MSDS

Properties

Description

Nutlin 3a, soluble in DMSO and ethanol and insoluble in water, prevents the degradation of p53 by inhibiting the MDM2-p53 interaction, leading to increased p53 levels and promoting apoptosis in p53-responsive cells. It targets p53/MDM2 interaction.

Molecular Weight

581.49

Molecular Formula

C₃₀H₃₀Cl₂N₄O₄

Targets

p53/MDM2 interaction: 90 nM

Form

Lyophilized powder

Purity

≥98%

Solubility

DMSO: 98 mg/mL (168.53 mM); Water: Insoluble; Ethanol: 98 mg/mL (196.53 mM)

Identity

Confirmed by NMR/HPLC/MS.

Stability

The product is stable for three years when stored at the recommended temperature in lyophilized powder.

Applications

Nutlin 3a can be utilized to activate p53 by disrupting its interaction with MDM2, aiding studies in apoptosis and cancer progression.

Storage

Store at -20ºC.