MDM2 inhibitor Nutlin 3a, Purity ≥98%

Synonym: 675576-98-4; Nutlin-3A; Nutlin-3; Nutlin 3a; (-)-Nutlin-3; Nutlin-3a chiral; 4-[[(4S,5R)-4,5-Bis(4-chlorophenyl)-4,5-dihydro-2-[4-methoxy-2-(1-methylethoxy)phenyl]-1H-imidazol-1-yl]carbonyl]-2-piperazinone; MDM2 inhibitor

MDL: MFCD14636430
CAS Number: 675576-98-4
Compound CID: 11433190

Product Size

5 mg; 10 mg; 25 mg; 50 mg; 100 mg

Price

Datasheet

Datasheet

MSDS

MSDS

Properties

Description

Nutlin 3a, soluble in DMSO and ethanol and insoluble in water, prevents the degradation of p53 by inhibiting the MDM2-p53 interaction, leading to increased p53 levels and promoting apoptosis in p53-responsive cells. It targets p53/MDM2 interaction.

Molecular Weight

581.49

Molecular Formula

C₃₀H₃₀Cl₂N₄O₄

Targets

p53/MDM2 interaction: 90 nM

Form

Lyophilized powder

Purity

≥98%

Solubility

DMSO: 98 mg/mL (168.53 mM); Water: Insoluble; Ethanol: 98 mg/mL (196.53 mM)

Identity

Confirmed by NMR/HPLC/MS.

Applications

Nutlin 3a can be utilized to activate p53 by disrupting its interaction with MDM2, aiding studies in apoptosis and cancer progression.