MDM2 inhibitor Nutlin 3b, Purity ≥98%

Synonym: 675576-97-3; Nutlin-3B; Nutlin-3; Nutlin 3; Nutlin 3b; FJA1772CVW; (+)-Nutlin-3; 4-[(4R,5S)-4,5-Bis(4-chlorophenyl)-2-(4-methoxy-2-propan-2-yloxyphenyl)-4,5-dihydroimidazole-1-carbonyl]piperazin-2-one; MDM2 inhibitor

CAS Number: 675576-97-3
Compound CID: 16755649

Product Size

5 mg; 10 mg; 25 mg; 50 mg; 100 mg

Price

Datasheet

Datasheet

MSDS

MSDS

Properties

Description

Nutlin 3b, soluble in DMSO and ethanol and insoluble in water, prevents the degradation of p53 by inhibiting the MDM2-p53 interaction, leading to increased p53 levels and promoting apoptosis in p53-responsive cells. It targets Mdm2.

Molecular Weight

581.49

Molecular Formula

C₃₀H₃₀Cl₂N₄O₄

Targets

Mdm2: 13.6 μM

Form

Lyophilized powder

Purity

≥98%

Solubility

DMSO: 90 mg/mL (154.77 mM); Water: Insoluble; Ethanol: 90 mg/mL (154.77 mM)

Identity

Confirmed by NMR/HPLC/MS.

Stability

The product is stable for three years when stored at the recommended temperature in lyophilized powder.

Applications

Nutlin 3b can be used as a less active enantiomer control in experiments investigating the role of p53 and MDM2 interaction.

Storage

Store at -20ºC.