MDM2 inhibitor RO-5963, Purity ≥98%

Synonym: 1416663-77-8; 2-[5-[(6-Chloro-7-methylindol-3-ylidene)methyl]-4-hydroxy-2-oxo-1H-imidazol-3-yl]-2-(3,4-difluorophenyl)-N-(1,3-dihydroxypropan-2-yl)acetamide; MDM2 inhibitor

CAS Number: 1416663-77-8
Compound CID: 136683438

Product Size

5 mg; 10 mg; 25 mg; 50 mg; 100 mg

Price

Datasheet

Datasheet

MSDS

MSDS

Properties

Description

RO-5963 prevents the degradation of p53 by inhibiting the MDM2-p53 interaction, leading to increased p53 levels and promoting apoptosis in p53-responsive cells.

Molecular Weight

518.9

Molecular Formula

C₂₄H₂₁ClF₂N₄O₅

Form

Lyophilized powder

Purity

≥98%

Identity

Confirmed by NMR/HPLC/MS.

Stability

The product is stable for three years when stored at the recommended temperature in lyophilized powder.

Applications

RO-5963 can be used to explore the modulation of the p53 pathway through MDM2 inhibition.

Storage

Store at -20ºC.