MDM2 inhibitor SAR-405838, Purity ≥98%

Synonym: 1303607-60-4; SAR405838; MI-77301; SAR-405838; MI-773 (SAR405838); 8570LZ3RCA; MDM2 inhibitor

MDL: MFCD28976052
CAS Number: 1303607-60-4
Compound CID: 53476877

Product Size

5 mg; 10 mg; 25 mg; 50 mg; 100 mg

Price

Datasheet

Datasheet

MSDS

MSDS

Properties

Description

SAR-405838, soluble in DMSO and warmed ethanol and insoluble in water, prevents the degradation of p53 by inhibiting the MDM2-p53 interaction, leading to increased p53 levels and promoting apoptosis in p53-responsive cells. It targets p53 and MDM2.

Molecular Weight

562.5

Molecular Formula

C₂₉H₃₄Cl₂FN₃O₃

Targets

p53; MDM2: 0.88 nM

Form

Lyophilized powder

Purity

≥98%

Solubility

DMSO: 93 mg/mL (165.33 mM); Water: Insoluble; Warmed ethanol: 29 mg/mL (51.55 mM)

Identity

Confirmed by NMR/HPLC/MS.

Applications

SAR-405838 can be used to study p53-MDM2 interaction and its potential as a cancer therapeutic by activating p53-mediated apoptotic pathways.