MDM2 inhibitor YH239-EE, Purity ≥98%

Synonym: 1364488-67-4; YH239-EE; Ethyl 3-(2-(tert-butylamino)-1-(N-(4-chlorobenzyl)formamido)-2-oxoethyl)-6-chloro-1H-indole-2-carboxylate; Ethyl 3-[2-(tert-butylamino)-1-[N-(4-chlorobenzyl)formamido]-2-oxoethyl]-6-chloro-1H-indole-2-carboxylate; MDM2 inhibitor

CAS Number: 1364488-67-4
Compound CID: 56943013

Product Size

10 mg; 25 mg; 50 mg; 100 mg

Price

Datasheet

Datasheet

MSDS

MSDS

Properties

Description

YH239-EE, soluble in DMSO and ethanol and insoluble in water, prevents the degradation of p53 by inhibiting the MDM2-p53 interaction, leading to increased p53 levels and promoting apoptosis in p53-responsive cells. It targets p53/MDM2.

Molecular Weight

504.41

Targets

p53/MDM2

Form

Lyophilized powder

Purity

≥98%

Solubility

DMSO: 85 mg/mL (168.51 mM); Water: Insoluble; Ethanol: 15 mg/mL (29.73 mM)

Identity

Confirmed by NMR/HPLC/MS.

Applications

YH239-EE can be used to study the inhibition of MDM2-p53 interaction and its therapeutic potential in cancer treatment.