MEK inhibitor AZD6244, Purity ≥98%

Synonym: Selumetinib; 606143-52-6; AZD6244; ARRY-142886; AZD 6244; 5-[(4-BROMO-2-CHLOROPHENYL)AMINO]-4-FLUORO-N-(2-HYDROXYETHOXY)-1-METHYL-1H-BENZIMIDAZOLE-6-CARBOXAMIDE; MEK inhibitor

MDL: MFCD11977472
CAS Number: 606143-52-6
Compound CID: 10127622

Product Size

100 mg; 250 mg; 500 mg; 1000 mg

Price

Datasheet

Datasheet

MSDS

MSDS

Properties

Description

AZD6244, soluble in DMSO and insoluble in ethanol and water, prevents the phosphorylation and activation of ERK leading to reduced cell proliferation and induced apoptosis in cancerous cells. It targets MEK1.

Molecular Weight

457.7

Molecular Formula

C₁₇H₁₅BrClFN₄O₃

Targets

MEK1: 14 nM

Form

Lyophilized powder

Purity

≥98%

Solubility

DMSO: 80 mg/mL (174.79 mM); Water: Insoluble; Ethanol: Insoluble

Identity

Confirmed by NMR/HPLC/MS.

Applications

AZD6244 (Selumetinib) can be used to study the inhibition of MEK1/2 to analyze its therapeutic effects in treating cancers.