MEK inhibitor BI-847325, Purity ≥98%

Synonym: BI-847325; 1207293-36-4; (Z)-3-(3-(((4-((Dimethylamino)methyl)phenyl)amino)(phenyl)methylene)-2-oxoindolin-6-yl)-N-ethylpropiolamide; BI 847325; BI847325; QXD8ZW7UVZ; 3-(3-(((4-((Dimethylamino)methyl)phenyl)amino)(phenyl)methylene)-2-oxoindolin-6-yl)-N-ethylpropiolamide; MEK inhibitor

CAS Number: 1207293-36-4
Compound CID: 135567102

Product Size

5 mg; 10 mg; 25 mg; 50 mg; 100 mg

Price

Datasheet

Datasheet

MSDS

MSDS

Properties

Description

BI-847325, soluble in warmed DMSO and ethanol and insoluble in water, prevents the phosphorylation and activation of ERK leading to reduced cell proliferation and induced apoptosis in cancerous cells. It targets Aurora A (human), Aurora B (Xenopus laevis), Aurora C (human), MEK1, and MEK2.

Molecular Weight

464.56

Molecular Formula

C₂₉H₂₈N₄O₂

Targets

Aurora A (Human): 25 nM; Aurora B (Xenopus laevis): 3 nM; Aurora C (Human): 15 nM; MEK1: 25 nM; MEK2: 4 nM

Form

Lyophilized powder

Purity

≥98%

Solubility

Warmed DMSO: 19 mg/mL (40.89 mM); Water: Insoluble; Ethanol: 1 mg/mL (2.15 mM)

Identity

Confirmed by NMR/HPLC/MS.

Stability

The product is stable for three years when stored at the recommended temperature in lyophilized powder.

Applications

BI-847325 can be employed to study dual inhibition of MEK and Aurora kinases in cancer research.

Storage

Store at -20ºC.