MEK inhibitor BIX 02189, Purity ≥98%

Synonym: BIX02189; BIX 02189; 1094614-85-3; 1265916-41-3; BIX-02189; (Z)-3-((3-((Dimethylamino)methyl)phenylamino)(phenyl)methylene)-N,N-dimethyl-2-oxoindoline-6-carboxamide; MEK inhibitor

CAS Number: 1094614-85-3
Compound CID: 135659062

Product Size

5 mg; 10 mg; 25 mg; 50 mg; 100 mg

Price

Datasheet

Datasheet

MSDS

MSDS

Properties

Description

BIX 02189, soluble in DMSO and ethanol and insoluble in water, prevents the phosphorylation and activation of ERK leading to reduced cell proliferation and induced apoptosis in cancerous cells. It targets EGFR, ERK1, and ERK5.

Molecular Weight

440.5

Molecular Formula

C₂₇H₂₈N₄O₂

Targets

EGFR: >6.3 μM; ERK1: >6.2 μM; ERK5: 59 nM

Form

Lyophilized powder

Purity

≥98%

Solubility

DMSO: 56 mg/mL (127.11 mM); Water: Insoluble; Ethanol: 75 mg/mL (170.24 mM)

Identity

Confirmed by NMR/HPLC/MS.

Applications

BIX 02189 can be used to examine the specific inhibition of MEK5 in the ERK5 signaling pathway.