Properties
Description
BIX02188, soluble in DMSO and ethanol and insoluble in water, prevents the phosphorylation and activation of ERK leading to reduced cell proliferation and induced apoptosis in cancerous cells. It targets EGFR, ERK1, ERK5, and JNK2.
Molecular Formula
C25H24N4O2
Targets
EGFR: >6.3 μM; ERK1: >6.3 μM; ERK5: 810 nM; JNK2: >6.3 μM
Solubility
DMSO: 39 mg/mL (94.54 mM); Water: Insoluble; Ethanol: 3 mg/mL (7.27 mM)
Identity
Confirmed by NMR/HPLC/MS.
Stability
The product is stable for three years when stored at the recommended temperature in lyophilized powder.
Applications
BIX02188 can be used to study the selective inhibition of MEK5 in various cellular contexts.