MEK inhibitor BIX02188, Purity ≥98%

Synonym: BIX02188; 1094614-84-2; 334949-59-6; BIX-02188; BIX 02188; (Z)-3-(((3-((Dimethylamino)methyl)phenyl)amino)(phenyl)methylene)-2-oxoindoline-6-carboxamide; (3Z)-3-[[[3-[(Dimethylamino)methyl]phenyl]amino]phenylmethylene]-2,3-dihydro-2-oxo-1H-indole-6-carboxamide; MEK inhibitor

CAS Number: 1094614-84-2, 334949-59-6
Compound CID: 135398492

Product Size

5 mg; 10 mg; 25 mg; 50 mg; 100 mg

Price

Datasheet

Datasheet

MSDS

MSDS

Properties

Description

BIX02188, soluble in DMSO and ethanol and insoluble in water, prevents the phosphorylation and activation of ERK leading to reduced cell proliferation and induced apoptosis in cancerous cells. It targets EGFR, ERK1, ERK5, and JNK2.

Molecular Weight

412.5

Molecular Formula

C₂₅H₂₄N₄O₂

Targets

EGFR: >6.3 μM; ERK1: >6.3 μM; ERK5: 810 nM; JNK2: >6.3 μM

Form

Lyophilized powder

Purity

≥98%

Solubility

DMSO: 39 mg/mL (94.54 mM); Water: Insoluble; Ethanol: 3 mg/mL (7.27 mM)

Identity

Confirmed by NMR/HPLC/MS.

Applications

BIX02188 can be used to study the selective inhibition of MEK5 in various cellular contexts.