MEK inhibitor GDC-0623, Purity ≥98%

Synonym: GDC-0623; 1168091-68-6; GDC 0623; RG 7421; GDC0623; 5-((2-FLUORO-4-IODOPHENYL)AMINO)-N-(2-HYDROXYETHOXY)IMIDAZO[1,5-A]PYRIDINE-6-CARBOXAMIDE; MEK inhibitor

MDL: MFCD25976760
CAS Number: 1168091-68-6
Compound CID: 42642654

Product Size

5 mg; 10 mg; 25 mg; 50 mg; 100 mg

Price

Datasheet

Datasheet

MSDS

MSDS

Properties

Description

GDC-0623, soluble in warmed DMSO and warmed ethanol and insoluble in water, prevents the phosphorylation and activation of ERK leading to reduced cell proliferation and induced apoptosis in cancerous cells. It targets MEK1.

Molecular Weight

456.21

Molecular Formula

C₁₆H₁₄FIN₄O₃

Targets

MEK1: 0.13 nM

Form

Lyophilized powder

Purity

≥98%

Solubility

Warmed DMSO: 89 mg/mL (195.08 mM); Water: Insoluble; Warmed ethanol: 5 mg/mL (10.95 mM)

Identity

Confirmed by NMR/HPLC/MS.

Stability

The product is stable for three years when stored at the recommended temperature in lyophilized powder.

Applications

GDC-0623 can be used to study the inhibition of MEK1/2 and analyze its effects on cellular proliferation and oncogenic pathways.

Storage

Store at -20ºC.