Properties
Description
GDC-0973, soluble in DMSO and ethanol and insoluble in water, prevents the phosphorylation and activation of ERK leading to reduced cell proliferation and induced apoptosis in cancerous cells. It targets MEK1.
Molecular Formula
C21H21F3IN3O2
Solubility
DMSO: 88 mg/mL (165.62 mM); Water: Insoluble; Ethanol: 41 mg/mL (77.17 mM)
Identity
Confirmed by NMR/HPLC/MS.
Stability
The product is stable for three years when stored at the recommended temperature in lyophilized powder.
Applications
GDC-0973 (Cobimetinib) can be used for studying the inhibition of MEK1/2 in cancer research.
